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Overall, the intimate relationship between defective DDR and cancer is clearly underlined by the numerous human genetic diseases that are associated with both DDR defects and predisposition to cancers including xeroderma pigmentosum, familial breast cancer, Bloom syndrome, MYH-associated polyposis, hereditary nonpolyposis colorectal cancer, etc. [ 59].
This is clearly underlined by normative sample data used in the IMAGE project, e.g., the CTRS [ 63]: a six year old girl having a score of thirteen on the CTRS DSM-IV hyperactivity scale deviates two standard deviations from the mean (T = 70), whereas a sixteen years old girl having the same score deviates twice as much, i.e. four standard deviations, from the mean (T = 90).
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This key role in the blood glucose homeostasis makes SGLT2 a promising target which has been clearly underlined by the results of preclinical and clinical studies.
The impact of the empty bed residence time (EBRT) on process performances was clearly underlined by varying the polluted air flow from 4 to 20 m3 h−1 corresponding to a variation in the EBRT from 63 to 13 s.
The importance of pharmacovigilance analyses has been clearly underlined by several studies that showed that case report/case series represented the most important source of evidence for drug withdrawals in Europe and the US [ 9].
The fact mentioned above are clearly underlining a clear disconnection between faculty development and digital scholarship.
The bigoted caricature of a Hollywood industry type is a hazy amalgam of hook-nosed Jew and sandal-wearing hippy – but this is clearly nonsense, underlined by one of Feinberg confidantes.
Most importantly, the evolutionarily conserved pattern described above is clearly recognizable (Additional file 6, 16, underlined), despite the putative D-arm (2 bp) having experienced severe reduction.
This is clearly shown by the model's results, which underline the strong stimulus to trade among developing countries, as the market size of the importers increases.
This is clearly shown by the results from our model, which underlines the strong stimulus to trade among developing countries as the market size of the importers increases.
Such cross-subsidization is clearly at odds with a market-led approach and a comparison with the housing domain underlines the peculiarity of these financial arrangements.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com