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Similarly, tumors with higher levels of dihydropyrimidine dehydrogenase (DPYD) may also be less responsive to capecitabine because this enzyme is chiefly responsible for 5-FU degradation and thus higher levels of DPYD may lead to lower levels of intratumoral 5-FU.
The independent Low Pay Commission is chiefly responsible for making recommendations for national minimum wage rates".
Merchant Marine Library Association, is chiefly responsible for the publication and distribution.
President Robert Mugabe's ruling Zanu-PF Party is chiefly responsible for this deterioration.
DNA is the chemical component of the chromosomes that is chiefly responsible for their staining properties in microscopic preparations.
The C.I.A. is chiefly responsible for keeping the other players up to date on the number & performance characteristics of Soviet systems.
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He was chiefly responsible for the MetroStars' fourth goal.
Two factors are chiefly responsible for the slowdown.
Peter Trego's responsible 89 was chiefly responsible for his side achieving maximum batting points.
She was chiefly responsible for administering non-military aid such as US economic grants.
From 1869 to 1881 he was chiefly responsible for modernizing and reorganizing Japan's fiscal system.
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