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Manetho apparently organized his dynasties by the capital cities from which they ruled, but several of his divisions also reflect political or dynastic changes that is, changes of the party holding power.
The secondary end points were overall survival (OS), progression-free survival (PFS) and pharmacodynamics parameters, that is, changes of circulating level of arginine and citrulline and anti-ADI-PEG 20 antibody.
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And then there is change of another kind: restoration.
"What it really needs is change of control," he says.
There are changes of heart and long delays.
"Those were changes of a sentimental nature," he said.
But now there are changes of manager and philosophy.
Our changes are changes of freedom, and truth, and correctness.
These are changes of style, strategy or marketing, not rules.
That's changed, of course especially during the past decade.
That's changed, of course.
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