It would be challenging to validate the effect of O2– on the Cdc25-mediated facilitation of the wt Ras GDP dissociation through monitoring of the GDP dissociation from wt Ras.
These predictions are challenging to validate experimentally due to the moderate (SQM>) to low (SDL>) peroxisome targeting efficiency of the original Arabidopsis decapeptides, making it difficult to investigate further reductions semi-quantitatively.
However, it is extremely challenging to validate these putative markers largely because of the enormous complexity of biological systems, heterogeneity of humans, and/or lack of high-throughput technology [37].
While the community knowledge of what constitutes "true protein interactions" in all cellular conditions remain poor, it is still challenging to validate the rest of PPIs that MetaGene data do not cover.
However, large-scale functional models derived from dynamic flux analyses or kinetic models are challenging to quantify and time-consuming to validate (van Eunen et al. 2012; Antoniewicz 2013), especially in multicellular eukaryotes (Allen et al. 2009).
Part of that discussion included validating the registrar: explaining that these patients can be challenging to manage.
Unfortunately, detecting and preventing such attacks is challenging and would require the registries to validate the ownership over the records at registration time.
The variability in the results also makes model validation difficult, as our ability to reproduce the experimental conditions (including individual rats' initial plasma and liver BA concentrations) within the context of a simulation is challenging; while our model is reasonably validated, further experimentation in this area will continue to improve our representation.
Although the main concern of the paper is challenging the use of correlation for validating language tests/test score meaning, a brief look at the meaning of correlation seems desirable at this point.
