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Escherichia coli expressed proplasmepsin-2 is capable of activation at acidic pH by autocatalytic cleavage of the pro part region, which results in products of different length.
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These particles were capable of activation and aggregation, thus proving their functionality.
In further support of this idea, our previous work demonstrates that a Tax mutant, TaxM22, is capable of Tak1 activation despite its defect in IKK activation [ 34].
We have demonstrated that highly purified recombinant S. aureus α-hemolysin is capable of inducing activation of caspase-1 through the NLRP3 inflammasome.
Although the assay we employed is capable of detecting activation of both caspases 3 and 7, since MCF7 cells are deficient in caspase 3 [ 60], the detected activity must be due to caspase 7 activation.
It was shown that this portion of ATHB12 is capable of transcriptional activation in yeast one-hybrid experiments [ 34] and functional complementation of a NaCl-sensitive calcineurin (CaN -deficient yeast mutant, only when the protein has a CaN -deficient 35].
One study has shown that NfsA is capable of CB1954 activation (Barak et al, 2006); however, to our knowledge, no earlier study has compared the activities of NfsA and NfsB with CB1954.
This observation is correlated with our novel finding that mislocalized Q344ter is capable of light-activation.
These results indicate that mislocalized Q344ter is capable of light-activation.
Whether mislocalized rhodopsin is capable of light-activation in vivo in the vertebrate retina has not been addressed.
We examined whether mislocalized rhodopsin is capable of light-activation by assessing the light-dependent rhodopsin phosphorylation by rhodopsin kinase [29], [30].
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