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The first measure (WM1) is calculated as average net monthly earnings divided by HM1 times 4.3.6 The second measure (WM2) has as denominator HM2 times 4.3.

For both algorithms, a statistic for the strength of DC (p or d) is calculated as average of topological changes over all correlation thresholds.

Fold change is the most intuitive approach used to represent the relative cell viability between two conditions, which usually is calculated as average cell viability (measured, for example, through an Alamar blue dye assay) over all wells in a condition divided by average viability over all wells in another condition.

Dominance was calculated as average dominance index and David's score.

Fluorescence intensity was calculated as average pixel count per field of view (n = 6, Figure 5A).

Log ratios were calculated as average peak intensity in the sample divided by average peak intensity in the control (Table S1).

The synonymous substitution rate was calculated as average of synonymous substitutions per codon (dS) for each branch in the gene tree of protocadherin subgroups.

When learning was calculated as average normalized gain, the mean gain was 0.26 (SD = 0.17).

F0 was calculated as average fluorescence during 100 frames when there was no activity.

Cost of illness was calculated as average cost per episode per case in ambulatory setup.

Generation interval for each individual was calculated as average age of parents at age of birth.