Natural antisense transcripts (NATs) have been broadly implicated in regulating gene expression and chromosome structure [29] [34].
Decreased expression of Ppara has also been observed in aging heart, liver, and kidney [72] and recently it has been broadly implicated in aging and systemic inflammation [73].
Finally, integrins are broadly implicated in bone metastasis due to their ability to induce mitogenic intracellular signaling.
In summary, disruption of the homeostatic balance between proliferation and apoptosis has been broadly implicated in cancer and silibinin tips the balance away from development of colorectal cancer.
These small interfering RNAs are broadly implicated in viral infection of mammalian cells, with either positive or negative effects on viruses' replication.
Additionally, GH has been broadly implicated in aging and neurogenesis, as neural precursor cells in the subventricular zone proliferate in response to central GH infusion [ 12].
Although published data implicates non-canonical Wnt signalling as a positive regulator of cell migration [ 30, 32, 33], DLG1 has been broadly implicated in maintaining integrity of the epithelium, aberrations of which are responsible for certain human diseases [ 34, 35].
MAP kinases, including ERK, p38, and JNK, have been broadly implicated as regulators of cell proliferation and migration in diverse cell types in response to a variety of stimuli [ 42- 44].
The interconnected HSP70 and HSP90 cytosolic chaperone systems (Kampinga and Craig, 2010; Hartl et al., 2011) have been broadly implicated in folding-dependent trafficking of CFTR and hERG (Loo et al., 1998; Ficker et al., 2003).
