When we examined GR ChIP-seq peaks, GR motifs with a nearby AP-1 motif are better bound, with a clear inflection at 150-bps.
At shorter distance, there is no unique spacing between the two motifs implying no direct physical interaction between GR and c-Jun (Additional file 1: Figure S6A) with GR and AP-1 motifs that are closer together being better bound.
If we fix δ at 0.5 bp and only fit for k1 and k3 using the Vmax -F dependence, the values are better bound (k1= 72±13 s-1 and k3= 35±3 s-1 for the wild-type; k1= 55±10 s-1 and k3= 75±13 s-1 for the mutant).
end{aligned} Hence, bound (2.2) is better than bound (2.1).
end{aligned} Hence, the upper bound (2.5) is better than bound (2.4).
It can be easily verified that the bound (6) is better than the bound (7).
Remark 3.1 Obviously, the upper bound in (22) is better than the bound (21).
In the following, we present a new lower bound which is better than the lower bound given in Theorem 2.
It is proved that this bound is better than the bound in (2).
Gen. Javed Iqbal) takes a view on the FMCT 180 degrees apart from Kidwai's," believing that it is better to bind India to current fissile material levels than wait for the full effect of the U.S.-India nuclear initiative, which will allow India to produce even greater amounts of plutonium.
