Meaningful genetic research requires large sample sizes that are best ascertained using multi-site study designs.
Because the details of underlying causal mechanisms for an outcome (i.e., all sufficient causes) are typically unknown, it is best to ascertain the validity of the method through simulations.
In Chandler's case, the measure of his worthiness is probably best ascertained by answering the question many New York fans have asked themselves all season: Where would the Knicks be without him?
A relatively safe and low-impact study comparing two widely used drugs to ascertain which is best seems morally permissible, even without a full-fledged informed consent process (Truog et al. 1999).
In order to ascertain the vitality of the residual bone, it is best to drill several holes into the bone ends and observe bleeding with the tourniquet deflated.
Moreover, "systemic" build-up of pesticides is impossible to ascertain with trees you have no control over; it's best to keep chemistry experiments to just the kitchen.
Further research is needed to ascertain whether these patients would be best categorized as 'NP-C positive' or 'NP-C negative'.
Therefore, it is important to collect data at key points of the life cycle, such as towards the end of the species' dispersal period, when the tendency of individuals to form group vs. nest alone can be best appraised and halfway during the egg-rearing period when the degree of communal brood care can best be ascertained.
Patients with previous neck problems probably have poorer prognosis [ 29, 52, 53], and the prognosis after isolated whiplash trauma would best be ascertained in cohorts excluding such patients.
Your vote should be recorded if it can be ascertained, and clearly the best indication is if there's an indentation".
