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The selenium-containing enzyme glutathione peroxidase, which plays a crucial role in prevention of damage due to radicals derived from lipid hydroperoxides, is believed to function via formation of an intermediate with a sulfur-selenium bond that is significantly more reactive toward a thiol nucleophile than a sulfur-sulfur (disulfide) bond.
The protein XRCC1 has no inherent enzymatic activity, and is believed to function in base excision repair as a dedicated scaffold component that coordinates other DNA repair factors.
The tumor suppressor p14ARF is widely deregulated in many types of cancers and is believed to function as a failsafe mechanism, inhibiting proliferation and inducing apoptosis as cellular response to a high oncogene load.
The highest affinity target of resveratrol identified so far is the oxidoreductase enzyme quinone reductase 2 (QR2), which is believed to function in metabolic reduction and detoxification processes; however, evidence exists linking QR2 to the metabolic activation of quinones, which can lead to cell toxicity.
During murine embryogenesis, GLI1 and GLI2 are believed to function primarily as transcriptional activators while GLI3 is believed to function primarily as a transcriptional repressor [6], [7].
EF-hand domain is believed to function as the Ca2+ sensor in the intracellular Ca2+ stores [14], [15] while SAM domain is thought to mediate protein-protein interactions of STIM proteins [17].
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Epidermal Langerhans cells (LCs) have been believed to function as professional antigen-presenting cells (APCs).
In both cases, the peptides were believed to function as both the reducing and protection agents.
These structures are believed to function as the new third route for the Sn diffusion.
Furanocoumarins are believed to function as phytoalexin (Beier and Oertli 1983) or allelochemical compound (Baskin et al. 1967).
Human β-defensins (hBDs) are believed to function as alarm molecules that stimulate the adaptive immune system when a threat is present.
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