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Currently, little evidence is available to define optimal nonsurgical management.
However, a relative paucity of level 1 evidence is available to define the exact role of surgery as a treatment modality for T2DM, especially in less obese subjects.
More recently, error-domain model falsification (EDMF) has been shown to be useful for situations where little information is available to define the probability density function (PDF) of modeling errors.
The exposure estimates made here have inherent limitations – only limited information is available to define the frequency and duration of mouthing behaviours for children of different ages.
However, little policy guidance or research evidence is available to define precisely how such services should be configured to optimise their effectiveness [ 21].
This suggests that relatively little marker information is available to define the sub-grouping within Groups 1 and 2, consistent with the weaker support for these subgroups described above.
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Furthermore, the guidance suggests the MABEL concept as a preclinical reference parameter in situations where no EFD studies are available to define the end of relevant systemic exposure.
Several algorithms are available to define which data are blinded (random selection, balanced random selection, experimental designs on the dependent or independent variables) where the employed algorithm influences the validation results.
At the time of data selection, no observatory data were available to define a more suitable selection index (e.g. the VMD index defined in Thomson and Lesur (2007)).
This adjustment leads by construction to much smoother transitions between the oceanic areas where sufficient data are available to define a grid and those where the model has to be used instead.
Despite the critical view of [22] on the data from [21], the authors decided to use this percentage to determine the target, simply because no other valid data were available to define a 'German standard'.
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