While it is not known how As concentrations vary with time at all of the reported water sources, we measured on a weekly basis the concentration of As at one thermal source over a period of one year and found the As concentrations to be variable; however, the cause of the variability is at present not understood.
The involvement of autophagy in tumour development is unquestioned but is at present incompletely understood.
The exact position of PI3Kβ in osteoclast signal transduction pathways is at present poorly understood.
However, the integration of information from these modalities is at present poorly understood.
The role of acidic Ca2+ stores in immune cells is, at present, poorly understood but our recent findings indicate that they may be crucially important for fighting infection.
hABCC10/MRP7 is capable of conferring a hABCC1/MRP1-type multidrug resistance phenotype in cellular models, but its physiological function is at present poorly understood [ 52].
Their selectivity relies on a supramolecular assembly of natively unfolded nucleoporin domains containing phenylalanine glycine (FG -rich repeats (FG -richt domains), in a way that is at prepeatspoorly understood.
Whether or not a change in the level of a single miR can prevail on the effect of the other miRs simultaneously targeting the same mRNA in physiological conditions is, at present, poorly understood.
It is at present incompletely understood how those non-canonical functions of TERT contribute to cancer development/progression and whether they affect the therapeutic efficacy of telomerase inhibition on cancer.
However, when there are more than two layers, the wrinkling behavior of the multi-layer system is, at present, not fully understood.
The exact contribution of the sirtuin family of NAD+-dependent histone deacetylases to longevity in metazoans is, at present, not completely understood but nonetheless regarded as significant.
