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The underlying question is important and the task design and analysis is appropriate to answer it.
The use of multiple sources of data (data triangulation) has been advocated as a way of increasing the internal validity of a study (i.e. the extent to which the method is appropriate to answer the research question)[ 8, 18- 21].
We believe that this design is appropriate to answer the research questions since on one hand it allows to examine the short-term (three months after baseline), mid-term (six months) and long-term (18 months) effects of the intervention, and on the other hand, the burden on participants (patients and clinicians) is not too high which will help to keep low study attrition.
The only study design that is appropriate to answer the key question of lung cancer screening, (i.e. is there a reduction of mortality from lung cancer) requires a prospective controlled randomized trial (RCT) in which subjects at risk for lung cancer are randomized to a screening arm (with regular CT) and a control arm (without regular CT).
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The design of a scientific study should be appropriate to answer the study question but independent of the theory which generated the study question.
In a letter to Mr. Whittingdale in which she agreed to testify, Ms. Brooks declared that it "might not be appropriate" to answer questions about the police investigation for fear of prejudicing it.
On reviewing this report, the readers should be able to identify whether these simulation modeling methods are appropriate to answer the problem they are addressing and to recognize the differences of these methods from other modeling approaches used typically in health technology assessment applications.
Therefore, the design and methods used in this study seem to be appropriate to answer our research questions.
Inclusion of this cohort in analyses would be appropriate to answer research questions that require pharmaceutical claims data only.
Collaborative research by a team requires consensus on study design to ensure the methods are appropriate to answer the study question.
However, the databases available (see online supplementary additional file I) contain key patient demographic and clinical variables that are appropriate to answer our research question.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com