Niemann-Pick C1 (NPC1), a highly conserved endo/lysosomal protein involved in cellular cholesterol trafficking, was recently identified to be an essential entry receptor for all known filoviruses (Côté et al., 2011; Carette et al., 2011; Miller et al., 2012; Ng et al., 2014).
He argued that the port where the U.S.-purchased cranes are meant to go is not an essential entry point for Yemen's supplies, and suggested that attention instead be paid to alternative ports in Saudi-controlled parts of Yemen.
CCR5 is an essential component of the entry mechanism for HIV; if there is no entry, there is no infection and there is no risk of transmission to others.
In further support of this, STRA8-positive cells were consistently detected in young adult mouse ovaries after HU-mediated blockade of premeiotic DNA replication, which is an essential step for meiotic entry in mammalian germ cells.
Viral entry is an essential target step for antiviral development, but FDA-approved HCV entry inhibitor remains exclusive.
HCV entry is an essential target step for antiviral development, but FDA-approved HCV entry inhibitor remains exclusive.
The prayer ritual is an essential component of Islam that requires entry into a state of physical purity (wudhu) through ablution, which is invalidated by voiding.
The NE-induced membrane depolarization is an essential requirement for opening VOCC, Ca2+ entry and smooth muscle contraction, and hence it represents an important mechanism of autonomic neurovascular control.
In this subcomplex, SufB acts as a scaffold, SufD is important for iron entry, and SufC is an essential ATPase.
The person who is obliged to lodge the entry summary declaration is an essential element of the customs legislation.
