Common interaction sequences should be amenable to optimization through good defaults, fast paths, or custom creation of macros.
While this report has focused on modifying glucagon to achieve hypoglycemia resistance, a large number of other hormones and signaling peptides have short half-lives and may also be amenable to optimization by XTEN addition.
This suggests that compounds targeting the emetine/pactamycin binding site are amenable to optimization, potentially leading to drugs more suited to clinical use.
Indeed, myriad reasons may mimic a flare of IBD but will not be amenable to optimization of the IBD-directed therapy [ 41].
We show that this weighted sum rate maximization (WSRM) problem can be recast into a primal decomposable form, which is amenable to alternating optimization (AO).
Moreover, due to its simple formulation, HCM is amenable to various optimization techniques, whereas FCM's formulation permits only modest acceleration.
If this hit is amenable to medicinal chemistry optimization and can be proved to be non-toxic then it may be developed further and become a lead for a specific target.
We therefore believe that ortholog detection is perhaps better viewed as an unsupervised learning problem that is amenable to graph-based cluster optimization.
If the above relationship is nonlinear, then the optimization problem is amenable to analytic solution only in some specific situations, while in the general case a suitable numerical procedure has to be utilized.
The method is amenable to automatic computation based on numerical optimization, and for instance, one can thus introduce performance objectives such as instantaneous control effort minimization into the design.
Therefore, we decompose the problem and propose a convergent alternate optimization that is amenable to distributed implementation.
