Unlike nuclear DNA, mitochondrial DNA is replicated independently of the cell cycle and not all molecules are always replicated (relaxed replication (Bogenhagen and Clayton, 1977)).
Microarray analysis of enriched heavy:light nascent DNA in Saccharomyces cerevisiae has revealed a genomic view of DNA replication timing profiles: some regions of the genome are always replicated early in S phase, some in the middle, and others at the end, due to a strict timing of (efficient) firing at origins [4].
The mechanism is related to chromosomal structure in which house-keeping genes are organized in such a way that they are always replicated earlier.
Women who marry younger (under 18 years in most studies) are at greater risk of IPV [ 11, 54- 56], although this finding is not always replicated [ 57] and older women are also at increased risk [ 13, 46, 47].
Acute or sub-chronic administration does not lead to the formation of inclusions and while α-syn inclusions have been detected in the study of some chronic models, this is not always replicated.
In other studies, vascular pathology in MCI (for example, white matter lesions) has been associated with decreased risk of progression of cognitive pathology and a more stable cognitive change profile [ 61, 62], although this is not always replicated [ 63].
10 However, these white matter imaging findings are not always replicated and there is a lack of correlation with clinical symptoms.
Unfortunately this practice is not always replicated by other agents, and we welcome more regulations to improve transparency in the industry".
This finding, however, is not always replicated [ 10].
However, it is also possible that CLM expression patterns in experimental models are not always replicated in human tissues.
