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Though it is not a flawless approach, when you have a conflict between two opposing rights – privacy and freedom of expression – it is always a difficult issue".
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Variations in the way samples are collected and stored in the clinic are always a difficult issue for the measurement of serum proteins with limited stability, but the problem will be magnified for multimarker, algorithmic tests, particularly if the component markers have different half lives in a blood sample.
Deciding what level of biological and biochemical detail to include is always a difficult and important issue.
'Oh, this is always a difficult one!
It is always a difficult target.
This is always a difficult call for the foreign teacher.
"It was always a difficult task.
That's always a difficult question.
It's always a difficult one.
"January's always a difficult time to do that.
"January's always a difficult time to bring players in".
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