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Based on these previous and our current findings, we can hypothesize that APP metabolism is altered at an early stage of fetal development, and its degree of alteration may be one of the most significant, among numerous molecular pathways that are implicated in the development of DS phenotypes.
Proteorhodopsin is another example, whose proton pumping machinery is altered at alkaline and acidic conditions.
The cellular morphology is altered at 10 μM SP600125 in that the cells resemble the senescent state, being enlarged and granular (not shown).
Previous studies have suggested that dopaminergic neurotransmission is altered at a central level in patients with chronic pain conditions [8 10].
In the particular case of PA6, it is clear that the usual shear banding plastic deformation mode is altered at least in its initiation step.
Here, we report studies in which the homodimeric LAGLIDADG homing endonuclease I-CreI is altered at individual side-chains corresponding to contact points to distinct base-pairs in its target site.
Similar(27)
Of alterations not defined before, UBR5, ZNF384 and TERT were found to be altered at higher frequency at 32, 19, 16%%, respectively.
Holiday plans have been altered at the last minute in an attempt to catch him.
The sense, and reality, of mutually assured destruction will not be altered at all.
There seemed no danger of that being altered at Sociedad's atmospheric Anoeta Stadium.
In reality, his contribution was limited to a few concluding scenes which had to be altered at the last moment.
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