Exact(9)
Computational analysis predicts that the N-terminal segment is also disordered.
This is supported both by the fact that the section of chain B near this part of the molecule is also disordered.
This is supported both by the fact that the section of chain D in this vicinity of the part of the molecule is also disordered (see above).
Likewise, the MeV NTAIL region is also disordered within the entire nucleoprotein, being equally accessible to monoclonal antibodies in isolation and within recombinant nucleocapsids, being highly susceptible to protease digestion and not visible in electron microscopy [6].
However, the changes are not large and the E22G mutant is also disordered in its monomeric state.
Both are mediated by an ID binding region in Med18, and the N-terminal domain (NTD) of Med11 is also disordered.
Similar(51)
A few peripheral elements in domain II that form the CP (H38, ES12) and the P stalk (H43, H44) and interact with domains III, VI and V (H33-H35) alsoalso disordered (Fig. 2E).
Moreover, the AKAPs are also disordered, which makes it difficult to work out how the kinases are held in position.
Additionally, residues spanning 154 165 (chain A) and 153 165 (chain B) are also disordered in the uncleaved structure.
Not only do most residues of human proteins fall outside domains, a large fraction of these residues are also disordered.
The 5′-end of the template was also disordered, and three bases on that side of the adduct were seen with higher thermal parameters.
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