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If the strong CYP3A4 inhibitor is discontinued, a washout period of approximately 1 week should be allowed before the temsirolimus dose is adjusted back to the dose used before initiation of the strong CYP3A4 inhibitor.
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That is to say, point A must be adjusted back to D′.
After the predictions of clearness index are made, these predictions are adjusted back to daily insolation for error calculation.
After 24 h, the pH of the extract was adjusted back to the original 6.7, and sterile distilled water at pH 6.7 was used to adjust the extract to the original concentration.
From Fig. 4 and Fig. 5, it can be seen that insecure operating point can be adjusted back into security region by re-distributing load in preventive control process.
To determine the effect of extreme pH on the stability of the fungicidal substance produced by E. brefeldiamun, its culture extract was adjusted to pH 2.0 or 12.0 for 24 h before being adjusted back to the original pH of 4.0.
Table 5 Conidial germination of Alternaria brassicola in culture extract of Eupenicillium brefeldianum adjusted to pH value of 2.0 or 12.0 for 24 h before being adjusted back to the original pH of 4.0 pH Germination a 2.0 0 12.0 0 4.0 Extract without treatment 0 4.0 Water (control) 98aSporee suspension mixed with the same amount of extract was incubated at 28°C for 4 h.
The pH of the lysate was adjusted back to 5.5 prior to cathepsin K activity assays.
The extract pH was adjusted back to pH 4.0 and heated to 55°C for 15 minutes.
The pH of remaining culture medium, named the flocculated medium, was adjusted back to the pH before flocculation by adding the necessary amount of 1M NaOH.
After 30 min, further folding buffer/inclusion body mixture (200 mL) was added into the original, and the heme concentration was adjusted back to 10 μ m by further addition of stock solution.
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