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When this pathway is active, however, the stem cells become heterogeneous in gene expression even though differentiation can largely be prevented by LIF.
In the cellular populations in which EGFR-NCE is active, however, it might impinge heavily on the regulation of EGFR signalling, since we have shown that while CME is primarily coupled with EGFR recycling to the cell surface (and therefore with sustainment of signalling), NCE is largely devoted to commit the receptor to lysosomal degradation (Sigismund et al, 2008).
While the SAC is active, however, the APC/C can still recognise some of its other substrates, notably cyclin A (Di Fiore and Pines, 2010; den Elzen and Pines, 2001; Geley et al., 2001; Wolthuis et al., 2008) and Nek2A Hayess et al., 2006).
The presence of P-bodies in myo1Δ strains suggests that the process of mRNA sequestration is active, however, the three representative down regulated RP mRNAs, RPS8A, RPL3 and RPL7B were present at equivalent levels in Dcp2p-mCh-positive immunoprecipitated fractions from myo1Δ and wild type cells.
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This does not mean that Chinese regulators have not been active, however.
While they are active, however, these accounts may have informal restrictions placed on them — some self-imposed — so they do not draw the scrutiny of bankers who may file suspicious-activity reports or would be required to report deposits over $10,000 in cash.
While the storm was active, however, the JTWC did not begin advisories until the following day.
When the storm was active, however, the strongest winds known at the time were a 10 minute wind of 35 mph, and a gust of 58 mph at Martinique Aimé Césaire International Airport.
Those with this signaling pathway being active, however, are more resistant to treatments that involve starvation [ 25].
Bortezomib was active, however, since c-Jun phosphorylation was induced as expected [ 21] at late time points.
All the mutants were active; however, major changes in the kcat values were measured (15- to 500-fold decrease).
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