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Importantly, the differentially expressed genes in HGPS indicated that Rb is a key regulatory component affected by LMNA mutation and that it is at the center of a signaling network that is abnormally active in the disease.
c-Myc encodes a helix-loop-helix transcription factor that is abnormally active in a large fraction of human malignancies.
In the majority of CRCs, Wnt signalling is abnormally active; consequently, we would expect genes downregulated by Wnt inactivation to be upregulated in cancer and vice versa for genes upregulated by Wnt inactivation.
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But they have been abnormally active in getting the show made.
Egan and his colleagues also showed with brain imaging that the prefrontal cortex was abnormally active in subjects with the faster enzyme when they were trying to keep in mind a set of numbers.
Furthermore, the modules would be abnormally active and better coordinated in DO, compared to the normal bladder.
His bond with Othello is abnormally strong.
Zhang's memory is abnormally retentive.
The most obvious signature of the ZS1C condensate is abnormally high toluene content and abnormally high K1 value.
The ROP is abnormally flat in this depth range.
That is abnormally high trading volume under anybody's definition.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com