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Nevertheless, in our view, the results fail to fully support the authors' claim that Ngn1 mediated induction of miR-9 controls the neuronal/astrocyte cell fate specification decision, and it is questionable whether in its current form the manuscript is a sufficient step forward to warrant publication in eLife.
It is our opinion that the critiques can be addressed largely or completely by textual changes – even if your work leaves many questions about the evolution of spindle orientation unanswered, it is a sufficient step forward to be of interest to the eLife readership.
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"It's not a sufficient step.
Thus, satisfaction of both criteria 1 and 2 at step n is a sufficient condition to obtain the true near-solidus melt composition after the nth iteration.
She received two-and-a-half years and Calcutt, in the court of appeal, successfully argued that contacting a member of the Soviet Embassy was a sufficient preliminary step in the venture to justify her conviction.
This is a necessary but not a sufficient step to further proof that Pax6 is indeed a direct regulator of expression of the gene of interest in a specific cell type.
Hence, a key event is a necessary, though not a sufficient, step in a process that results in a specific adverse effect.
President Juan Manuel Santos of Colombia, in a brief television appearance, said the release was an important — but not a sufficient — step for peace talks, and he demanded that the FARC release all civilian hostages it is still holding for ransom.
We found that 1000 years was a sufficient number of time steps for the population to evolve fairly stable heritable growth and maturation.
Our data thus indicate that inhibition of the PP2A B56 γ subunit is a crucial and sufficient step for apoptin activation.
Based on the studies described above, we hypothesized that loss of PTF1A is a necessary and sufficient step in acinar cell reprogramming, the initiation of PanINs, and the progression of PDAC.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com