In examining the PIs affinity for CYP450 enzymes, lopinavir is a substrate of the enzyme CYP3A4, while ritonavir is a substrate of CYP1A2, 2B6, 2D6, and 3A4.
In this study, we report that PCNA is a substrate of NEDD8.
Slurry is a substrate of value and almost free of charge.
Our previous work showed that snapin is a substrate of RNF13.
It is a substrate of drug transporter ABCB1 as well as of cytochrome P4503A (CYP3A).
Of the major ACE inhibitors currently available, temocaprilat is a substrate of hepatic transporters.
This factor is required for Tat trans-activation and is a substrate of an associated cellular kinase.
Folic acid is a substrate of dihydrofolate reductase, an enzyme involved in making nucleotides that is potently inhibited by methotrexate.
Oxygen is a substrate of hemoglobin.
Akt is a substrate of the chaperone Hsp90.
The topoisomerase II inhibitor doxorubicin is a substrate of P-glycoprotein (Pgp, ABCB1) and etoposide is a substrate of the multidrug resistance-associated protein (MRP, ABCC1).
