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That is a significant shift.
This is a significant shift.
It is a significant shift in our thinking about our nearest evolutionary cousins.
For George Weston, the acquisition is a significant shift in strategy.
The deal is a significant shift in strategy for HSBC, which has typically focused on servicing the very wealthy.
"There is a significant shift in the campaign once you've proven you're capable of winning," said one senior Gore aide.
What it certainly represents is a significant shift in the compass guiding Britain's membership in the EU.
The move is a significant shift for Time Inc., the largest magazine publisher in the United States.
"This is a significant shift in the presentation of this fungal infection, and quite concerning," she said.
That is a significant shift for a country where owning a home remains deeply rooted in the culture.
For the Tories, who argued until recently that state money would be pernicious, this is a significant shift.
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CEO of Professional Science Editing for Scientists @ prosciediting.com