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Even getting on the ballot is a significant obstacle.
That is a significant obstacle because agreement between the two countries usually is needed to accomplish major reforms in Europe.
The environmental organizations said that the extensive use of the prison system by Dell and others is a significant obstacle to the creation on a profitable recycling industry.
The cost of flying Maggie, who weighs 8,000 pounds, is a significant obstacle, with some estimates approaching $200,000, Mr. Lampi said.
Flooding is a significant obstacle to the development of Bangladesh, which is home to two of the largest river systems in the world: the Brahmaputra and the Ganges.
Recent reports from the Asian Development Bank and the IMF argue that poor infrastructure is a significant obstacle to Indonesia's growth.
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Mr. Diogenous said that getting authorization to transfer money abroad to pay for his vehicles initially took 10 days or longer and was a significant obstacle to business.
Nearly 20 centuries later the banks, densely covered now in heather and coarse tussock grasses, are still surprisingly intact, and the ditches outside them continue to be a significant obstacle to the aspiring visitor.
That policy may be a significant obstacle for borrowers, since many of the people facing foreclosure originally financed their homes with second mortgages — called "piggyback loans" — or borrowed against the homes' equity after buying them.
According to Unicef data, 74% of Bangladeshi girls are married before the legal age of 18. "Child marriages are a significant obstacle to development in Bangladesh," said Myrna Evora, country director of Plan Bangladesh, a children's charity that campaigns against early marriage.
In a statement, the Competition Commission in Britain said it had concluded that Ryanair's shareholding had been a significant obstacle to Aer Lingus's ability to merge or form partnerships with other airlines, limiting Aer Lingus's strategic options as it seeks to remain competitive during a recent wave of airline consolidation in Europe.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com