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The phrase "is a significant issue" is grammatically correct and commonly used in written English.
It is typically used to describe a problem or situation that is important or noteworthy. Example: Climate change is a significant issue that needs to be addressed by governments and individuals alike.
Exact(58)
And the cost is a significant issue.
"But it still is a significant issue.
Control of the police is a significant issue.
"This is a significant issue," said one Hague aide.
For private equity firms, paying a breakup fee is a significant issue.
For the first time in memory, family violence is a significant issue in an Australian election.
This is a significant issue for Yahoo, and it will likely be long term and durational.
To be sure, whether Clinton mishandled classified information is a significant issue.
"I think that is a significant issue for people," he said.
Several shareholders say the lack of a clear succession plan is a significant issue.
"The ongoing headline risk is a significant issue, and I think the market shares that sentiment," he said.
More suggestions(15)
is a significant emission
is a prominent issue
is a huge issue
is a noticeable issue
is a momentous issue
is a salient issue
is a tremendous issue
is a large issue
is a notable issue
is a sizable issue
is a considerable issue
is a significant theme
is a significant controversy
is a significant subject
is a significant item
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com