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Ruthenium 360 (Ru360) is a relatively specific blocker of mitochondrial Ca2+ uptake via the Ca2+ uniporter [47].
Although 8CPT-2'-OMe-cAMP is a relatively specific activator of Epac proteins, it is a weak and less effective activator of PKA [28], [30], [35].
2-Deoxy-D-glucose (2-DG) is a relatively specific blocker for glycolysis because it cannot be further metabolized by hexokinase.
CFTRinh172 is a relatively specific inhibitor of this chloride channel that may interact with the sixth transmembrane helix in CFTR, probably preventing pore opening [16].
The possibility that the increased sensitivity to LatB might be secondary effect can not be excluded, although LatB is a relatively specific actin depolymerization drug which acts by forming a high affinity complex with monomeric actin.
MPO is a relatively specific indicator for PMN presence (Guo & Ward, 2005).
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Knockouts of various alternative pathway components have demonstrated roles in maturation of B cells [23] and induction of TH17 cells [24], as well as differentiation of osteoclasts [8], suggesting that this pathway might be a relatively specific target for autoimmune diseases, especially those associated with bone loss.
To be precise, serum IgA was a relatively specific marker for IgAN, however fibrinogen and manifestation were two relatively specific markers for non-IgAN.
From an analysis of KO mice, SOCS2 has been shown to be a relatively specific negative regulator of GH STAT5 [ 13, 14].
The ability to convert resveratrol to piceatannol has been surmised to be a relatively specific property of CYP1B1 (Potter et al, 2002b).
This white matter profile was identified after taking disease severity into account; moreover, a similar emphasis of white matter tract alterations was identified when the bvFTD group was compared with the AD group, suggesting that involvement of these tracts may be a relatively specific index of pathologies in the bvFTD spectrum.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com