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This is a profound issue of daily consequence that technological advances have wrought.
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The question of promoter specificity of AF-4 family members is a profound issue that is the subject of active investigation in multiple laboratories.
There is a profound disorientation of ideas.
This is a profound article of faith.
"There is a profound church-state issue here.
In that context, the cover image of the May 2013 issue of CPT is a profound metaphor, in which blind monks describe an elephant by the individual "components" they feel with their hands.
This is a profound loss.
"That is a profound consequence".
This is a profound question.
This is a profound cultural shift.
At the nub of the argument the colonists had used to discredit the authority of Parliament and the British monarchy was a profound distrust of any central authority that issued directives from a great distance.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.
Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com