It is a particularly problematic disease in chickens (due to their intense rearing conditions), costing the industry £38 million per year in the UK alone and, extrapolating from this, over 2 billion US dollars to the world's farmers and poultry industries annually [1].
HAT caused by Trypanosoma brucei gambiense is a particularly problematic disease and starts to surge during conflict in endemic areas.
As our heuristics are still evolving, problematic disease names (e.g. 'Interferon' or 'memory') are entered into a 'cheat list' and removed from the system, with suggestions for improvements ticketed in our Bugzilla databases (http://www.bugzilla.org/), to be addressed in future releases.
Drug resistance is problematic in microbial disease, viral disease and cancer.
The casual user is not equipped to select from these non-orthogonal ontologies and selecting a more specific child term is more problematic; the Disease Ontology alone has 16 subclasses.
Indeed, the evolution of such mechanisms is problematic when disease prevalence is low, as because of low prevalence their benefits are seldom experienced while their costs are always expressed.
As seen with classical swine fever, the growing population of wild boars is problematic for animal disease control, particularly if the infection reaches endemicity (6 ).
Exposure misclassification due to migration is perceived to be most problematic for diseases with a long lag between exposure and disease onset [ 3, 5, 6].
This approach is instantly problematic when the disease of concern has never been observed within the population at risk, which means that no baseline can be established; however, it also poses other challenges.
A significant number of non-food products contain ingredients derived from grains that can be problematic with celiac disease or gluten intolerance.
