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The O6-methylguanine-methyltransferase (MGMT) promoter methylation status is a predictive parameter for the response of malignant gliomas to alkylating agents such as temozolomide.
In this reanalysis of the ABCSG-6a trial, we demonstrate that BMI is a predictive parameter regarding extended endocrine treatment with an AI.
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Nevertheless, their study showed that 6 weeks after initiation of treatment with anti-TNF drugs, the quantitative parameter (Ktrans) had significantly decreased in treatment responders, indicating that it may be a predictive parameter of the response to treatment.
As this could not be shown for tamoxifen in these trials, BMI might be a predictive parameter regarding endocrine therapy.
Taking this into account, BMI might be a predictive parameter whether to use AI-based or tamoxifen-based endocrine treatment.
A small caliber artery ipsilateral to the ischemic region was a predictive parameter for FP versus TP discrimination (ROC area, 0.84 ± 0.04 vs. 0.59 ± 0.05; p < 0.0001).
Da Rocha et al 15 found S100B to be a predictive parameter for fatal outcome in patients with IHI and in multi traumatised patients.
Increased serum PCT levels may be a predictive parameter of infection and MOF development during AP and correlated with high mortality rate.
It has also been recently reported, during the 2005 San Antonio meeting, that MYC status could be a predictive parameter of tumour response to anti-HER2 therapy (Gianni et al, 2005).
Further studies might be needed to determine if there is a predictive morphological and measurable parameter in a larger group of patients.
Thrombocytopenia is a well-known transient symptom of this condition (15), and we found that severe thrombocytopenia (<60 x 10/L) was a prognostic parameter predictive for consecutive severe acute renal failure (serum creatinine >620 µmol/L).
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CEO of Professional Science Editing for Scientists @ prosciediting.com