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"Cognitive tests show no signs of dementia in these participants now, but we'll be interested to see if a lower clearance rate is a predictive marker for future diagnosis of Alzheimer's disease," said Bateman.
Overexpression of EGFR is a predictive marker of therapeutic response and several lines of evidence suggest that EGFR is an excellent target for tumor therapy.
In addition, downregulation of E-cadherin is a predictive marker of invasiveness and metastatic potential of many forms of cancer, including breast and gastric tumors [12], [13], [14], [15].
CA 125 has also been evaluated in preclinical serum specimens, and each study suggests that CA 125 is a predictive marker that becomes increasingly powerful with proximity to diagnosis [4] [6].
Along this line of argument, it is tempting to speculate that serum sFcεRI is a predictive marker for the onset of allergies that may be detectable even before serum IgE levels are elevated.
We have demonstrated that this protein was a strong predictive factor for poor overall survival in breast cancer patients [11] and recently, another group has shown that YB-1 is a predictive marker of prognosis in non-small cell lung cancer [19].
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Genetic variability possibly predicts treatment outcome and could be a predictive marker to select the group benefiting from a certain treatment.
First, CTC can survive chemotherapy and therefore can be a predictive marker for the effectiveness of treatment.
KRAS mutation status has been reported to be a predictive marker of tumor response to epidermal growth factor receptor (EGFR) inhibitors.
For example, somatic mutations in the tyrosine kinase domain of the epidermal growth factor receptor was shown to be a predictive marker for a greater efficacy of gefitinib in patients with non small cell lung cancer [7, 8].
MMP8 was also detected in the chorion during labor and was proposed to be a predictive marker for preterm delivery [39], [40].
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CEO of Professional Science Editing for Scientists @ prosciediting.com