Because a circulating soluble form of EPCR (sEPCR) has been described in sepsis, and its concentration possibly correlates with the severity of the illness, the respective contributions of mpEPCR and sEPCR is a matter of clinical relevance.
The exact form the meaning-bestowing intention must take is a matter of controversy, but that is not of pressing relevance here.
For the sake of consistency, the topography in which LVI is searched should be considered the border of neoplasia, as data on the lymphangiogenesis in inner areas of the tumor and its possible relevance for prognosis is a matter of debate, perhaps because of differences in the markers used [ 24, 31, 37].
However, the relevance of MGMT-immunoreactivity is a matter of intense discussion especially when MGMT-immunoreactivity is correlated to MGMT promoter methylation status [17] [19], [32], [33].
The prognostic relevance of Maspin expression is a matter of debate.
The clinical relevance of cortical αS pathology in relation to dementia is a matter of intense debate.
Epithelial tumour cell apoptosis has been extensively studied in CRC, but still the relevance of the apoptotic index as a prognostic factor is a matter of debate (Koornstra et al, 2003; de Bruin and Medema, 2008).
The clinical relevance of detection of respiratory viruses such as rhinovirus and coronavirus is a matter of debate.
While the relevance assumption can be tested, whether the instruments are uncorrelated with the error is a matter of economic reasoning.
All in all, the relevance of these various saposin- and prosaposin-deficient mice to the study of GD pathology is a matter of debate.
