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It is a limiting component of telomerase, and thus essential for tumor, germ, and stem/progenitor cell proliferation [17], [19], [20], [21].
1) The authors propose that Nbp1 is a limiting component for SPB insertion.
Taken together, the results of the present study identify Munc18b as an essential gene that is a limiting component of the exocytic machinery of epithelial cells and MCs.
These findings indicate that Jak/Stat3 participate directly in molecular reprogramming and that activation of this pathway is a limiting component.
4EBP1 directly interacts with eIF4E, which is a limiting component of the multi-subunit complex that recruits 40S ribosomal subunits to the 5′ cap of mRNAs.
NDD1 does not directly bind to DNA but interacts with FKH1 or FKH2, both of which bind directly to DNA, and NDD1 is a limiting component of the complex that activates G2/M genes.
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The commensurate reductions in Munc18b expression and stimulated degranulation of MCs from heterozygous mutant mice indicates that Munc18b can be a limiting component of the regulated exocytic machinery for leucocytes as well as epithelial cells.
Fatigue is a limiting factor in structural component life.
Thus, although dLBR might be important, it is not a limiting component of the nuclear architecture in Drosophila cells, at least during the first days of development [33].
We conclude that the dMAN1 protein is not a limiting component of the nuclear architecture in Drosophila cultured cells.
Interestingly, no change in p27 phosphorylation was observed in transgenic mice, suggesting that some other component may be a limiting factor for p27 destruction.
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