Blaming and sacking managers has been a frequent response to the pressures.
Signposting people to their GP was a frequent response to queries of a medical nature.
Although that study made use of cocaine, it may be that changes in axon guidance molecules are a frequent response to drugs of abuse (see [ 37]).
Hepatic fibrosis is a frequent reparative process in response to chronic liver injury and inflammation, which is mainly attributed to hepatic stellate cell (HSC) activation.
Consistently, regression of metastatic mutant B-RAF melanomas is a frequent sign of the response to administration of PLX4032, a close analogue to PLX4720, suggesting that induction of apoptosis may be a major biological consequence of inhibition of mutant B-RAF.
Disseminated intravascular coagulation (DIC) is a frequent complication of systemic inflammatory response syndrome (SIRS) [ 1].
Therefore, over-expression of hypoxia-inducible transcription factor-1 (HIF-1), a "master" gene in the hypoxic response, is a frequent occurrence in many tumor cells, including NSCLC [ 2].
DIC is a frequent complication of systemic inflammatory response syndrome (SIRS) and is deeply involved in the prognosis of conditions ranging from SIRS to sepsis to severe sepsis and septic shock [ 15, 16].
TP53 (encoding the tumor protein p53), a master regulator of cell stress responses, is a frequent mutational target in many solid tumors [ 22- 24], and pancreatic cancer is no exception; mutations in TP53 occur in up to 75% of pancreatic cancers, most often by point mutation or small intragenic deletion [ 23, 24].
Accordingly, inhibition or loss of at least some aspects of the apoptotic response pathways is a frequent characteristic of cancers in humans and model systems.
