Sentence examples for is a direct functional from inspiring English sources

To further examine whether PLD1 is a direct functional target of miR-638 in GC cells, we performed a series of functional restoration assays.

Thus, we conclude PKIα is a direct functional target of miR-155.

Recently, cystatin C was identified as a novel substrate for MMP2 in cell-based proteomic analysis, suggesting that there is a direct functional link between MMP2 and cystatin C [40].

Fifthly, since there is no information at present on whether the SNP in the ANK3 gene (rs10994336) is a direct functional variant or a tagging SNP, which may reflect the effect of another, as yet unknown, variant which has a direct functional effect on both risk of BD and visual sustained attention.

An alternative avenue of investigation has been to assess whether there is a direct, functional relationship between epigenetics and genetics at particular risk alleles.

Taken together, these data suggest that PTEN is a direct functional target of miR-21, and its expression is regulated by miR-21 in CCC.

These drugs target two concurrent oncogene addictions in these tumours, both of which are a direct functional consequence of mutational BRAF activation.

Moreover, in vitro and in vivo data demonstrate that treatment with thapsigargin, which activates the UPR via disturbance of calcium homeostasis, is accompanied by increased tau phosphorylation, suggesting there may be a direct functional connection between UPR activation and tau phosphorylation.

To verify whether there was a direct functional link between Notch pathway and drug-induced apoptosis, we assessed by flow cytometry the effect of the blockade of Notch-1, -2 and -4 or whole Notch signaling on the expression of active caspase-3, Bcl-2, NF-κB, p53 in CLL cells in culture and coculture conditions in presence of drugs for 3 days.

From these data, PLK1 is a direct and functional target gene in NSCLC.

We also established that MMP7 is a direct and functional target of miR-148a.