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Consistently, in our study, MTSS1 protein expression was lost more frequently in poorly differentiated tumors than in well-differentiated tumors, suggesting that MTSS1 is a differentiation marker for gastric cancer.
The epithelial mesenchymal transition (EMT) is a differentiation switch that directs polarized epithelial cells to differentiate into mesenchymal cells.
Fat cell formation or adipogenesis is a differentiation process by which undifferentiated preadipocytes are converted in to fully differentiated adipocytes which store energy as fat and make the subjects obese [ 13].
"There is a differentiation between 'always on resilience' and 'resilience that is always on'", he adds.
It is a differentiation factor as well as a potent mitogen.
It is a differentiation which could not satisfy the most elementary mind in the kindergarten of logic or the most forgiving person in the Sunday School of legal-moral responsibility.
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EHF is a differentiation-associated transcriptional repressor that interacts with 5-TTCCGA/TCGGAA-3 PRE elements (Figure 1A) [67-69] [67-69]C stands confIHCed increastainsF abundanconfirmedskincreasedcularly within cEHF nuclei abundanceasal epinermis (Additional file 10).
We propose that XBP-1 activation in B cells is a differentiation-dependent event, and that the failure of XBP-1-deficient B cells to become plasma cells involves misregulation of key transcription factors, possibly due to altered BCR signalling.
Nonetheless, XBP-1WT/μS−/− plasmablasts activate XBP-1 with similar kinetics as do XBP-1WT/MD4 plasmablasts, demonstrating conclusively that XBP-1 activation is a differentiation-dependent event unlinked to accumulation of misfolded IgM.
Here, we show that in the B cells, whose capacity to secrete IgM has been eliminated, XBP-1 is induced normally on induction of differentiation, suggesting that activation of XBP-1 in B cells is a differentiation-dependent event, but not the result of a UPR caused by the abundant synthesis of secreted IgM.
That's a differentiation most people have lost".
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