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It is commonly admitted that VIN associated with lichen sclerosus is a differentiated type and that overexpression of p53 is present, contrary to what happens in undifferentiated type VIN, induced by HPV, and in which overexpression of p16 is encountered [ 5].
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However, in other tissues where cell fusion occurs after γ-IR, it is reported that the host fusion partner is a differentiated cell type that is not known to be actively cycling [1], [11], [22].
In contrast, the intestinal phenotype is a very well differentiated type, with low proliferative activity and a lack of MSI [ 17].
Because IMR90 is a fully differentiated cell type, it does not show similar tendencies.
This suggests that, again, cohabitation may be associated with the time invested in housework only in contexts where it is a more differentiated union type from marriage, which selects individuals with less conventional expectations about men's and women's participation in unpaid work.
TP53 mutation and allelic deletion of the APC gene are detected more frequently in the intestinal phenotype of GC. 8, 16 In contrast, CDH1 gene mutation is detected in differentiated type GC a showing gastric phenotype.
The multipotent cell type is the most differentiated type of stem cells [ 3].
Fillmore C. and Kuperwasser C. supposed that CD24+ population was mainly characterized by less differentiated basal type of breast cancer, and CD44+ cells caused the development of luminal form of breast cancer, being more differentiated type of tumor [37].
Most interesting thing in present case is that other types of liposarcoma were found simultaneously in colon and retroperitoneum; the retroperitoneal liposarcoma was well differentiated type, and colonic one was mixed type.
SCLC is a type of less-differentiated and highly aggressive tumor with a poor prognosis.
DNA methylation failure at genes specifically expressed in differentiated cells is a well-described type of aberrations present in iPSCs.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com