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Dawe, R. K., Reed, L., Yu, H.-G., Muszynski, M. G. & Hiatt, E. N. A maize homolog of mammalian CENPC is a constitutive component of the inner kinetochore.
During replication, the primase is a constitutive component of the replisome, the protein complex associated with the replication fork [3].
The present results indicate that uPA is a constitutive component of the inflamed synovial fluid in RA joints.
Claudin 7 is a constitutive component of mammary epithelium at all stages of development, maintaining a level of gene expression that is approximately proportional to the amount of epithelial tissue in the gland.
Nonetheless, in a previous study, we showed that HCV nucleocapsid (HCV-Cp), devoid of envelope proteins, is a constitutive component of cryoglobulins [ 22] and is potentially able to cause cryoglobulin-mediated tissue injury in vivo, via gC1q-R [ 23].
ChAT is the enzyme that synthesizes ACh; because it is a constitutive component of ACh nerve terminals, its activity provides an index of the development of ACh projections (Dam et al. 1999; Happe and Murrin 1992; Monnet-Tschudi et al. 2000; Qiao et al. 2003; Richardson and Chambers 2005; Slotkin et al. 2001).
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We find claudin 7 to be a constitutive component of the mammary epithelium, where it is localized to the basolateral regions of the cell.
In addition, resident macrophages are a constitutive component of skeletal muscle, relevant for inflammatory responses associated with muscle injury, dystrophies and endotoxemia [ 23, 24].
As a control, we monitored the binding of another factor, Orc2 (a subunit of the origin recognition complex) known to be a constitutive component of chromatin and found it was also precipitated quantitatively.
COX-2 thus appears to be a constitutive component of not only proliferating myoblasts but also of differentiating myotubes in these two cell lines, observations again supporting its importance in muscle cell physiology.
AXIN1 appears to be a constitutive component of β-catenin degradation complex for maintenance of basal life activity while AXIN2 is considered to be an inducible component that is upregulated in response to increases in β-catenin levels and thus serves to limit the duration and intensity of the Wnt signal [ 50, 51].
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