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The enforced retirement of Ryan Harris is a considerable setback to Australia five days before the first Test, though it is not on the same scale as the injury to Glenn McGrath about 40 minutes before the start of the Edgbaston Test of 2005.
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That was always going to be a considerable setback.
That was a considerable setback for an unelected, already unpopular President like Truman.
The absence of their captain would be a considerable setback for City given that they will also be without the suspended Yaya Touré and the latest bulletin on David Silva's knee injury indicates he might not be fully fit either.
Plainly, the alternative would be a considerable setback for Van Gaal given the consistently upward trajectory of De Gea's career since those early days in Manchester when he could be a danger to his own team and Eric Steele, then United's goalkeeping coach, talked of him being a poor trainer, "lazy" when it came to learning English, and eating "too many tacos".
The figures are a considerable setback given the progress made since last year's border crisis, when agents apprehended about 68,000 unaccompanied minors along the border and about the same number of family units.
Aleksandr Zheleznyakov, a scientist with the Federation of Russian Cosmonautics, said the latest mishap was "a considerable blow to the industry's image, particularly taking into account our many setbacks in the last couple of years".
That is a considerable understatement.
This is a considerable theatrical achievement.
That is a considerable difference.
Purchasing a treadmill is a considerable investment.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com