It is a considerable one.
The same difficulty meets us in using the currents of rivers and waterfalls as exists in regard to tides unless the current is fast and the waterfall is a considerable one".
That he was subsequently ruled out of the Paris Saint-Germain tie on account of his weakened calf does not necessarily have to be a grievous setback for City, but it is a considerable one when their hopes of reaching a first Champions League semi-final depend to a great extent on the team's ability to defend coherently.
Should we make a leap of faith (admittedly, it is a considerable one) and accept that the evolutionary modalities of this simple, virtual system reflects those of real biological systems, this gives us a genuinely novel outlook at the evolution of complexity.
And that role, it turns out, was a considerable one, especially for the slave-trading kingdoms of western and central Africa.
Coaxing him back to his best is a considerable undertaking, one Louis van Gaal could not pull off at United.
Though hot new devices like the iPhone 4S and the Galaxy S III have been spared from the sales injunction, the list is still a considerable one — in all, the court banned the sales of the iPhone 4, iPad 2, Galaxy Nexus, Galaxy S, and Galaxy S II devices.
The cost of unsafe abortion to the health system is therefore a considerable one.
It is a considerable achievement, albeit one in which successive managerial place-men have had relatively little input, and in which the desire of the fans to be transported, seduced with dreams of something larger, has been essentially ignored.
This is a considerable task, and one could envision success if a multidisciplinary approach is used with collaboration between municipal authorities, medical professionals, public health, entomologists and community stakeholders.
For example, if three treatments, A, B, and C, are being compared in an MTC and all treatments have been compared head to head in a few RCTs, there is a considerable risk that one of the three pooled head-to-head treatment comparisons will yield an over- or underestimate of the comparative treatment effect due to the play of chance (imprecision).
