This was probably caused by a close linkage between Tph2 and Ms11 loci at LG 8, the latter responsible for male sterility in the nuclear male sterile (NMS) line P21 [ 21] from which Ms11 was introgressed to nmsT2100.
Hence, a priori, a close linkage is expected between regional- and local-scale factors.
Intriguingly, in the course of exploration of the positive correlation between tumor burden and high lactate levels, a close linkage was discovered between the intracellular accumulation of lactic acid and the antitumorigenic immune response.
Secondly, as a kind of conditional pathogenic bacteria, the possibility that healthy carrier sows harbor S. suis 2 is capable of causing disease under specific circumstances cannot be ruled out [ 5], suggesting a close linkage of S. suis serotype 2 from healthy sows and diseased pigs.
This phenomenon may be due to an alternative hypothesis that HLA may only be a genetic marker, which is in close linkage with another NPC predisposition locus.
Besides identifying a real causative polymorphism directly responsible for the phenotype, allelic association may point to a polymorphism that is in close linkage disequilibrium to the associated marker.
This may indicate that the associated marker is in close linkage disequilibrium with an uncharacterised variant in the protein coding region, or that the functional SNP may cause its effect by epigenetic or histone modification.
The variant that we have used in this study is in close linkage disequilibrium (LD) with variation within a transcription factor binding site located 5' of CRP that is associated with circulating concentrations of CRP and thought to be functional.[43] [45] It is unlikely that this functional variant, or one in close LD with it, will have pleiotropic effects.
For a successful purging strategy where a transgene is placed in close linkage with a gene or genomic block that causes a lower fitness in the wild habitat (Gressel 1999; Stewart et al. 2003), clear indications are needed of those negatively selected regions.
Alternatively, if a transgene is placed in close linkage with a gene or genomic block that causes a lower fitness in the wild habitat compared to the wild relative, it will have a smaller chance to introgress (Gressel 1999; Stewart et al. 2003).
