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The ribosome, a complex of rRNAs and ribosomal proteins (rP), is a central player of gene expression, translating mRNA into protein (Fig. 1A).
Our results demonstrated that PTP1B is a central player of the mechanisms triggered by APAP in hepatotoxicity, suggesting a novel therapeutic target against APAP-induced liver failure.
The circadian clock is a central player of the photoperiod pathway [ 36], and H2O2 serves as an input signal that affects the transcriptional output of the clock and flowering time [ 35].
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With the previous finding that β-actin expression changed in breast cancer drug resistance cells, this prompted us to hypothesize that β-actin and cytoskeletal genes may be involved in the prostasin-directed chemoresistance development as actin gene is believed to be a central player of cell shape and movement and a key component of cytoskeleton.
The family of lysyl oxidase (LOX) enzymes is a central player in remodeling of cancer-related ECM.
The Bay itself is a central player, as thousands of fans arrive on ferries and anticipate a Splash Hit home run into McCovey Cove, sprinkled with kayaks and sailboats.
BCL2 is a central player in apoptosis of eukaryotic cells favoring survival by inhibiting cell death.
Androgen receptor is a central player throughout development of prostate cancer, even after androgen deprivation therapy [ 2].
Moreover, the drug screen assay depends on the inhibition of cell proliferation which is a central player in the efficacy of the selected drug.
The transcription factor E2F-1 is a central player in the regulation of proliferation and functions by activating transcription of G1/S/G2-phase genes.
AKT, also known as protein kinase B (PKB), a serine/ threonine kinase, is a central player in processes downstream of activated PI3K signaling, involving in the regulation of both glycolytic and oxidative metabolism [ 19].
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