Sensory irritation involves stimulation of the trigeminal nerve (fifth cranial nerve), and near triggering concentrations is generally considered to be a physiological and not a toxic response in that no tissue damage or cellular injury is involved (Gaffney and Paustenbach, 2007; Paustenbach and Gaffney, 2006; Dalton, 2002, 2003).
There has also been additional evidence to support the hypothesis that gastrointestinal irritation is involved in crib-biting in horses.
For instance, it prevents the recurrent, unnecessary and tiresome disputes about the location of the defensive wall and the ball during free kicks as well as the ensuing irritation of everyone involved.
My reaction involved more irritation than anything else.
Secondly, most striking was the GPs irritation about not being involved in the development of the Care Program for the Geriatric Patient.
Furthermore, it may also be a result of injury or irritation of brain areas involved in glucose regulation, a theory supported by the association of hyperglycemia with strokes involving the insula (22).
A few too many errors and the message is soon lost beneath the irritation of the errors involved.
But in lab tests, researchers found the acetals they created from mixing flavors into e-liquids were even more effective in triggering molecular receptors involved in lung irritation — the same receptors that maintain irritation and inflammation in people with asthma or those who have inhaled smoke or fumes, the study found.
Complaints associated with land-applied sewage sludges primarily involve irritation of the skin, mucous membranes, and the respiratory tract accompanied by opportunistic infections.
With respect to formaldehyde-induced sensory irritation, this phenomenon involves a dose-response continuum in which low levels begin to trigger the sensory nerves, but the rate of removal (i.e., detoxification) of formaldehyde from tissues in the nose and upper airways is sufficient to limit accumulation and prevent tissue damage.
