In small children, in addition to airborne irritants and atopy, respiratory viruses may also play a role in initiation or exacerbation of asthma (Schwarze and Gelfand 2000).
Moreover, the reagents used are nonirritant in contrast for NBD-Cl which cause high irritant effect to the skin these attributes, in addition to the satisfactory sensitivity and reproducibility as well as the convenience and simplicity, make the two proposed methods suitable for routine analysis in quality control laboratories.
In addition to systemic effects, irritant effects on the skin and mucous membranes deserve special attention.
Validated tools to predict respiratory sensitization and to translate irritancy assays to asthma potency are needed, in addition to diagnostic biomarkers that assess and differentiate allergy versus irritant-based asthmatic responses.
Most degradation products are considered corrosive or irritant and therefore feature strongly in that category in addition to the parent amine.
In addition to its role in detecting irritant chemicals, TRPA1 has been controversially implicated in noxious cold and mechanical sensation; therefore, we used the selective TRPA1 antagonist HC-030031 to evaluate its effects on oxaliplatin-induced neuropathy.
Host responses to ectoparasites are recognised as immunologic or allergic in addition to being traumatic, toxic, or directly irritant [ 14].
In addition to its asphyxiant properties, hydrogen sulfide also acts as an irritant to the eyes and mucous membranes.
19 In addition to anti-inflammatory properties, colloidal oatmeal also exhibits antioxidant, anti-irritant, and immunomodulatory effects.
DOI: http://dx.doi.org/10.7554/eLife.11750.009 In addition to its function as a thermoreceptor, TRPA1 is a highly conserved chemosensor of electrophile irritants such as N-methylmaleimide (Macpherson et al., 2007; Kang et al., 2010).
