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What comes first irrevocably changes what follows.
In her poetry class at Columbia University, she makes all her students memorize poems, an experience, she says, in an age where memorization is frowned upon, that irrevocably changes them.
What jolts there are come mostly in a terrifying opening stretch that sees French television news anchor Marie (Cécile De France) holidaying in south-east Asia with her boss/lover, swept up in a tsunami and enduring a near-death experience that irrevocably changes her.
Side effects are a concern because APR-246 binds to the amino acid cysteine and irrevocably changes it and cysteines are abundant on numerous other proteins besides p53.
Well, that's a nice surprise.
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Hawaiian culture was irrevocably changed.
But the playbook had been irrevocably changed.
Many aspects of human activity were irrevocably changed.
After 9/11 our perception of the world irrevocably changed.
Some "starter castles" irrevocably change the character of established neighborhoods.
A couple of decades later, that picture had irrevocably changed.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com