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Laws against smoking have irreversibly shifted attitudes.
By the time Hibbert returned less than two minutes later, the game had irreversibly shifted.
Unlike other GPCRs (with the exception of a handful of protease-activated receptors), animal rhodopsins are covalently bound to an inverse agonist, 11- cis-retinal, such that the equilibrium is essentially irreversibly shifted to the inactive state until the photoisomerization of the chromophore occurs.
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It is quite possible that this licence fee settlement marked the moment that the balance of power between government and the BBC shifted irreversibly.
But despite Brazil's efforts to slow deforestation, scientists say the Amazon is approaching a tipping point where enough tropical biomass has been lost to cause large areas of the forest to shift irreversibly into savanna or other less biodiverse landscapes.
Both of these criticisms have merit.For things that clearly do have the springlike quality of shifting irreversibly if pulled (or pushed) too far, like the collapse of ice sheets or the melting of permafrost, a boundary system that seeks to stop you getting too close to the threshold seems as sensible as a safety rail is on a parapet.
The MECs generated from the BLG model appeared to show some developmental plasticity and instability, irreversibly developing a spindled non-epithelial morphology when shifted to the permissive temperature, and acquiring the ability to form colonies in soft agar, a characteristic of transformed cells.
The formal potential shifted anodically as the organic phase biosensor responded irreversibly to substrate (camphor) under anaerobic and aerobic conditions in acetonitrile.
Environmental management that proactively avoids thresholds, so that the system does not shift (perhaps irreversibly) into another state with different structures and processes, will be more effective in sustaining the resources being managed.
Calculations of the share of the free Co II) ion as well as of the particular complex species existing in solution beside the oxygen adduct (regarding dioxygen bound both reversibly and irreversibly) indicated quite significant values for the systems with alanine and asparagine in those cases the of oxygenation reaction is right shifted to a relatively lower extent.
Something shifted.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com