Sentence examples for irreversibly modify from inspiring English sources

Both H2O2 and these compounds can irreversibly modify protein thiols, with deleterious consequences.

The electrochemical activation reaction observed for oxygen rich graphitized carbons is known to irreversibly modify the properties of the material.

The most effective TG2 inhibitors to date are small-molecule peptidomimetics featuring electrophilic warheads that irreversibly modify the active site catalytic cysteine (CYS277).

Over the past decade targeted covalent inhibitors have undergone a renaissance due to the clinical validation and regulatory approval of several small molecule therapeutics that are designed to irreversibly modify their target protein.

Covalent labeling (CL) with reagents that can irreversibly modify solvent accessible amino acid side chains is an effective way to encode structural information into the mass of a protein, as this information can be read-out in a straightforward manner using standard MS-based proteomics techniques.

Mechanistic investigation reveals that the compound A1 could effectively and irreversibly modify the TrxR by virtue of the above optimal biochemical parameters, and convert this antioxidant enzyme into a reactive oxygen species (ROS) promoter, resulting in a burst of the intracellular ROS including H2O2 and O2–.

However, some epitopes are irreversibly modified by formalin while others are not.

In practice, this handle can be a novel peptide sequence, which forms a 'tag' that is selectively and irreversibly modified by enzymes.

Playing a pugilist can be faked, but if you want to look really convincing, you have to pump up – and, if things are done authentically, you can never be sure that your pretty face won't be irreversibly modified in the process.

In addition, our data indicate that shoreline modifications have led to cumulative impacts that have irreversibly modified Great Lakes nearshore coastal habitats and the processes that create and maintain them.

There is, however, a great difference in the ability to store charge of the polymer's p- and n-doped forms: a great amount of injected negative charge irreversibly modifies the structure of pQTDO.