Sentence examples for irreversibly modifies from inspiring English sources

There is, however, a great difference in the ability to store charge of the polymer's p- and n-doped forms: a great amount of injected negative charge irreversibly modifies the structure of pQTDO.

The epoxide irreversibly modifies the active site Cys, forming a thioether bond 67, 68.

However, some epitopes are irreversibly modified by formalin while others are not.

Both H2O2 and these compounds can irreversibly modify protein thiols, with deleterious consequences.

The electrochemical activation reaction observed for oxygen rich graphitized carbons is known to irreversibly modify the properties of the material.

In practice, this handle can be a novel peptide sequence, which forms a 'tag' that is selectively and irreversibly modified by enzymes.

The most effective TG2 inhibitors to date are small-molecule peptidomimetics featuring electrophilic warheads that irreversibly modify the active site catalytic cysteine (CYS277).

Playing a pugilist can be faked, but if you want to look really convincing, you have to pump up – and, if things are done authentically, you can never be sure that your pretty face won't be irreversibly modified in the process.

Over the past decade targeted covalent inhibitors have undergone a renaissance due to the clinical validation and regulatory approval of several small molecule therapeutics that are designed to irreversibly modify their target protein.

In addition, our data indicate that shoreline modifications have led to cumulative impacts that have irreversibly modified Great Lakes nearshore coastal habitats and the processes that create and maintain them.

The co-crystal structure reveals that the inhibitor binds in the active-site cleft, irreversibly modifying the active-site cysteine; however, the catalytic histidine is still misaligned as seen in the native structure, suggesting that the inhibitor binds to an inactive form of the enzyme.