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Playing a pugilist can be faked, but if you want to look really convincing, you have to pump up – and, if things are done authentically, you can never be sure that your pretty face won't be irreversibly modified in the process.
However, some epitopes are irreversibly modified by formalin while others are not.
In practice, this handle can be a novel peptide sequence, which forms a 'tag' that is selectively and irreversibly modified by enzymes.
In addition, our data indicate that shoreline modifications have led to cumulative impacts that have irreversibly modified Great Lakes nearshore coastal habitats and the processes that create and maintain them.
This process occurs in two stages, generating first reversibly "primed" and then irreversibly modified fibroblasts with tumor-promoting properties [1].
It has been previously proposed that tumor cells can induce a reversibly "primed state" in normal fibroblasts, in which the fibroblasts can promote tumorigenesis even though they do not have all the characteristics of the irreversibly modified CAFs [1].
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Both H2O2 and these compounds can irreversibly modify protein thiols, with deleterious consequences.
The electrochemical activation reaction observed for oxygen rich graphitized carbons is known to irreversibly modify the properties of the material.
The most effective TG2 inhibitors to date are small-molecule peptidomimetics featuring electrophilic warheads that irreversibly modify the active site catalytic cysteine (CYS277).
Over the past decade targeted covalent inhibitors have undergone a renaissance due to the clinical validation and regulatory approval of several small molecule therapeutics that are designed to irreversibly modify their target protein.
There is, however, a great difference in the ability to store charge of the polymer's p- and n-doped forms: a great amount of injected negative charge irreversibly modifies the structure of pQTDO.
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